Pet CBD Research
Hemp extract is the new frontier, and for many it simply seems like the next gold rush for those looking to strike it rich. But, as more research is conducted, the positive uses of full spectrum hemp extract and CBD for pets is being revealed. As with any treatment for your pet, evidence-based treatments are vital, which is why studies into the numerous effects of CBD on pets is ongoing.
What is full spectrum hemp extract and why is it important?
Full spectrum means that all of the cannabinoids and terpenes that can possibly be present, are present. While there are thousands of cannabinoids and terpenes present in each plant, and it is not possible to preserve every single one during the manufacturing process, full spectrum means that none of the cannabinoids were purposefully removed.
One of the reasons full spectrum is so important is because the cannabinoids and terpenes all work together to enhance each other. This effect (called the entourage effect) makes it possible for different cannabinoids to interact to achieve maximum effects.
A study conducted by UNICAMP in Campinas, Brazil found that full spectrum, CBD-rich extracts are more beneficial to people and pets when compared to a CBD isolate. In fact, the study states:
“Adverse effects were more frequent in products containing purified CBD than in CBD-rich extracts. CBD-rich extracts seem to present a better therapeutic profile than purified CBD, at least in this population of patients with refractory epilepsy.”
Using CBD to treat multiple ailments
Full spectrum hemp extracts and hemp-derived CBD can be used to treat multiple ailments at once. A 2010 study published in Immunobiology states:
“Cannabinoids have been shown to act as potent immunosuppressive and anti-inflammatory agents and have been shown to mediate beneficial effects in a wide range of immune-mediated diseases such as multiple sclerosis, diabetes, septic shock, rheumatoid arthritis, and allergic asthma.”
Studies supporting CBD for arthritis and chronic pain
Research has consistently shown that CBD can help humans who suffer from osteoarthritis, but it is also a promising treatment for dogs suffering the same ailment.
Cornell University’s College of Veterinary Medicine recently conducted pharmacokinetics study on cannabinoids for dogs. This 8-month double-blind study was the first of its kind for Cornell and studied dogs suffering from osteoarthritis. Dogs in the study saw a significant decrease in pain and increase in activity, with no side effects. In fact, the study concluded the following:
“Pharmacokinetics revealed an elimination half-life of 4.2 h at both doses and no observable side effects. Clinically, canine brief pain inventory and Hudson activity scores showed a significant decrease in pain and increase in activity (p < 0.01) with CBD oil. Veterinary assessment showed decreased pain during CBD treatment (p < 0.02). No side effects were reported by owners… This pharmacokinetic and clinical study suggests that 2 mg/kg of CBD twice daily can help increase comfort and activity in dogs with OA.”
A study published in 2006 in Current Neuropharmacology also states that CBD has therapeutic benefits for both people and pets suffering from chronic pain and acute chronic pain episodes.
CBD as a viable treatment for seizures
In a 2017 double-blind study conducted by Colorado State University’s James L. Voss Veterinary Teaching Hospital, neurologist Stephanie McGrath assessed the short-term effect of CBD on seizure frequency in 16 dogs. Dogs in the trial were randomly assigned a placebo or a hemp-derived CBD treatment for 12 weeks. Nine dogs received CBD while seven were given a placebo. All of the dogs in the study suffered from seizures.
Through the study, McGrath found that 89 percent of dogs who received CBD in the clinical trial had a reduction in the frequency of seizures. Additionally, McGrath saw a significant association between the degree of seizure reduction and the amount of CBD concentration in the dog’s blood.
This was not the only study to find CBD to be a successful anti-epileptic supplement for pets. Yamazaki University of Animal Health Technology in Japan conducted a similar experiment wherein three dogs who suffered epileptic seizures were given hemp-derived CBD for eight weeks. Researchers found a decrease in seizure intervals in two of the three dogs studied. The dogs were given varying amounts of CBD, and the dog who received the lowest number of mg of active CBD showed little to no improvement, while the dog who was administered 1700 mg showed the highest level of improvement. Of note: the same study’s findings show that the dogs showed a decrease in barking even when other dogs nearby were excitable.
Hemp to help with tumors and cancer
One of the primary uses of hemp extract is to treat cancer and tumors. Research conducted by A.B. Hancock Jr. Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt Ingram Comprehensive Cancer Cent concluded that “The antiproliferative and apoptotic effects produced by some of these pharmacological probes [CBD] reveal that the endocannabinoid system is a promising new target for the development of novel chemotherapeutics to treat cancer.”
Another study published in 2018 found that CBD inhibits the growth of cancerous cells in mice with pancreatic and bladder cancer. Not only did CBD inhibit cancerous cell growth, but also proved to prevent future cancerous growths in the mice treated with CBD. The conclusion of this study noted that CBD could be a viable option to treat cancer in both humans and animals.
Additionally, several studies have concluded that CBD has the potential to treat several cancers, including breast cancer, in humans which is prompting research into the effects on animals (see references).
CBD for anxiety, stress, and sleep issues
CBD is known primarily as an anti-anxiety medication for both people and pets for good reason. A study published in Current Neuropharmacology states:
“CBD seems to be a promising drug for the treatment of [panic disorders].”
A 2013 article published in Neuropharmacology also found that:
“In addition to modulating basal anxiety states, recent studies suggest an important role for the endocannabinoid (eCB) and glucocorticoid systems in the modulation of emotional states and extinction of aversive memories in animals.”
This means that CBD can help in facilitating extinction of aversive memories which treats PTSD and anxiety or panic disorders in people and animals.
Research is also promising that CBD is a viable treatment option for sleep disorders in people and pets. A 2019 study published in the Permanente Journal found that CBD has a calming effect on the central nervous system and can improve the amount and depth of sleep in those suffering sleep disorders and CBD is better tolerated than other psychiatric medications.
Unlike many traditional oral medications, research has proven that CBD is effectively and quickly absorbed into the bloodstream. A study conducted by the Department of Pharmacy, School of Pharmacy at Hebrew University in Jerusalem, Israel concluded that “CBD was observed to have a large volume of distribution [in dogs studied].”
This article will be updated as research is continually conducted and published. Below is a list of resources, research, and studies with additional information regarding full spectrum hemp CBD and its therapeutic uses.
To learn more visit www.CBDDogHealth.com.
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About Angela Ardolino
Angela Ardolino is passionate about animals and has dedicated her life to providing all-natural relief to of pets of all ages and breeds. Ardolino has worked with animals for over 20 years and operates Fire Flake Farm, a rescue farm in Lutz, FL. A medical cannabis expert, Ardolino holds a degree in the therapeutic uses of cannabis from the University of Vermont School of Medicine and is the founder of CBD Dog Health. Combining her background in broadcast journalism and her passion for pets, Ardolino is the host of a pet-centric podcast, “It’s a Dog’s Life” on CannabisRadio. Additionally, she is the owner of Beautify the Beast, a natural pet salon and spa. Ardolino has five dogs and up to 10 residing on her farm who she is fostering or boarding. Visit www.AngelaArdolino.com and www.CBDDogHealth.com to learn more.